反应详情

A mixture of methyl-3-hydroxyphenyl acetate (14.1 g, 85.0 mmol), chloromethylquinoline (15.1 g, 85.0 mmol), cesium carbonate (29.0 g) and acetone (300 ml) is refluxed for 40 hours. The mixture is filtered through Celite and silica gel and the solvent is removed in vacuo to give 25.4 g (97% yield) of oil.

1. temperatureis refluxed for 40 hours
2. filtrationThe mixture is filtered through Celite and silica gel
3. customthe solvent is removed in vacuo