HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Methyl-3-[(2-quinolinyl)methoxy]benzeneacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-(Chloromethyl)quinoline | HCID 20394 | — |
| Reactant | 2-Methylresorcinol, acetate | HCID 23469416 | — |
| Product | Methyl-3-[(2-quinolinyl)methoxy]benzeneacetate | HCID 19934822 | 97% |
Reaction Steps
A mixture of methyl-3-hydroxyphenyl acetate (14.1 g, 85.0 mmol), chloromethylquinoline (15.1 g, 85.0 mmol), cesium carbonate (29.0 g) and acetone (300 ml) is refluxed for 40 hours. The mixture is filtered through Celite and silica gel and the solvent is removed in vacuo to give 25.4 g (97% yield) of oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04769461 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-16616ef10d9f443188b751e53a260a33 |
| Source note | uspto-grants-1988_09 |