Sodium Hydroxide → 3-(2-Quinolinylmethoxy)benzeneacetic acid

HRID 622163노트

반응식

HRID 622163 반응식
C[O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)[CH:6]=1.[OH-].[Na+]>O1CCCC1>[N:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:21]=[CH:22][C:13]=1[CH2:12][O:11][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([OH:23])=[O:2])[CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19934822Methyl-3-[(2-quinolinyl)methoxy]benzeneacetate

생성물 1

HCID 1285433-(2-Quinolinylmethoxy)benzeneacetic acid수율 94%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The ester of (A) above (19.5 g, 63.4 mmol) is dissolved in tetrahydrofuran (150 ml) and 1N NaOH (150 ml) is added. The reaction is heated at reflux for 3 hours. The tetrahydrofuran is removed in vacuo and the remaining solution is adjusted to pH 3 using 1N HCl. A precipitate forms which is filtered and dried, giving 17.5 g (94% yield) of product, m.p. 128°-130° C.

후처리

  1. temperatureThe reaction is heated
  2. temperatureat reflux for 3 hours
  3. customThe tetrahydrofuran is removed in vacuo
  4. filtrationA precipitate forms which is filtered
  5. customdried

출처 및 근거

ORD 기록
ord-9f8fd836e4804c188da76d7fcfd0f53c
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04769461

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