反应详情

The ester of (A) above (19.5 g, 63.4 mmol) is dissolved in tetrahydrofuran (150 ml) and 1N NaOH (150 ml) is added. The reaction is heated at reflux for 3 hours. The tetrahydrofuran is removed in vacuo and the remaining solution is adjusted to pH 3 using 1N HCl. A precipitate forms which is filtered and dried, giving 17.5 g (94% yield) of product, m.p. 128°-130° C.

1. temperatureThe reaction is heated
2. temperatureat reflux for 3 hours
3. customThe tetrahydrofuran is removed in vacuo
4. filtrationA precipitate forms which is filtered
5. customdried