反应详情

5.0 g of 2-methoxy-3,4-methylenedioxybenzaldehyde was suspended in 30 ml of methanol, to which 4.31 g of 40% methylamine aqueous solution (2 equivalent) was added. 59 mg of 5% Pd/C catalyst (0.1 mol %) was added to the obtained reaction mixture and hydrogenation was carried out at ordinary temperature and atmospheric pressure. Absorption of hydrogen was completed in about 2 hours to quantitatively obtain N-methylbenzylamine derivative. The catalyst was filtered out and excessive methylamine, water formed and methanol solvent were distilled off to obtain an oily N-methyl-2-methoxy-3,4-methylenedioxybenzylamine. (Yield 100%).

1. additionwas added
2. customAbsorption of hydrogen
3. filtrationThe catalyst was filtered out and excessive methylamine, water
4. customformed
5. distillationmethanol solvent were distilled off