Hydrazine hydrate (1:1) → HCID 86160846, compound

HRID 622223Notes

Reaction equation

HRID 622223 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)=O.O.[NH2:18][NH2:19]>C(O)CO>[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)=[N:18][NH2:19]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21915324HCID 21915324, compound

Product 1

HCID 86160846HCID 86160846, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

A mixture prepared form 18 g of (3-bromothien-2-yl) (4-methoxyphenyl)methanone, 12 ml of hydrazine hydrate (99%) and 120 ml of ethylene glycol was stirred at 120° for 2 hours. Thereafter, the mixture was cooled and diluted with 1000 g of ice water and quickly extracted with ether (3×500 ml). The combined ether solution was washed four times with water to remove unreacted hydrazine and dried over anhydrous magnesium PG,54 sulfate overnight.

Workup

  1. temperatureThereafter, the mixture was cooled
  2. extractionquickly extracted with ether (3×500 ml)
  3. washThe combined ether solution was washed four times with water
  4. customto remove unreacted hydrazine
  5. dry with materialdried over anhydrous magnesium PG,54 sulfate overnight

Sources & evidence

ORD record
ord-71d7c6a4c46e412085b0a85d749f01b5
Source dataset
uspto-grants-1988_09
Patent number
US04769472

Reaction notes

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