反应详情

A solution of 44.4 g. of 2,4-dihydroxy-3-propylacetophenone, 42.2 g. of 6-chlorocapronitrile, 33.2 g. of potassium carbonate and 4.0 g. of potassium iodide in one liter of methyl ethyl ketone was allowed to reflux for three days. The reaction mixture was filtered and the filtrate was evaporated in vacuo. Chromatography of the residue over silica gel (0-30% ethyl acetate gradient in hexane) gave 53.6 g. of the title product as an oil.

1. temperatureto reflux for three days
2. filtrationThe reaction mixture was filtered
3. customthe filtrate was evaporated in vacuo
4. customChromatography of the residue over silica gel (0-30% ethyl acetate gradient in hexane) gave 53.6 g