反应详情

4-Chloro-2-fluoro-5-nitroaniline (19 g) and 3,4,5,6-tetrahydrophthalic anhydride (15.2 g) were dissolved in acetic acid (50 ml) and refluxed for 6 hours. After being allowed to cool, the resultant mixture was poured into water and extracted with toluene. The toluene layer was washed with water, an aqueous sodium hydrogen carbonate solution and water in order, dried and concentrated. The residue was crystallized from ethanol to give 20 g of N-(4-chloro-2-fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide. M.P., 157°-157.5° C.

1. temperaturerefluxed for 6 hours
2. temperatureto cool
3. extractionextracted with toluene
4. washThe toluene layer was washed with water
5. dry with materialan aqueous sodium hydrogen carbonate solution and water in order, dried
6. concentrationconcentrated
7. customThe residue was crystallized from ethanol