1-[1-(2-Chlorophenyl)butyl]-1H-imidazole-5-carboxylic acid → HCID 23707461, compound

HRID 622314Notes

Reaction equation

HRID 622314 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([N:12]1[C:16]([C:17]([OH:19])=[O:18])=[CH:15][N:14]=[CH:13]1)[CH2:9][CH2:10][CH3:11].C[O-:21].[K+:22]>CO>[OH2:18].[OH2:21].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([N:12]1[C:16]([C:17]([O-:19])=[O:18])=[CH:15][N:14]=[CH:13]1)[CH2:9][CH2:10][CH3:11].[K+:22]

Participants

4

Reactant 2

HCID 143051431-[1-(2-Chlorophenyl)butyl]-1H-imidazole-5-carboxylic acidHCID 23664618Potassium methoxide

Product 1

HCID 23707461HCID 23707461, compoundYield 26.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1 part of 1-[1-(2-chlorophenyl)butyl]-1H-imidazole-5-carboxylic acid, 80 parts of methanol and 35.9 parts of a potassium methoxide solution 0.1N was stirred for 1 hour at reflux temperature. The reaction mixture was evaporated and the residue was dried in a dry pistol at 70° C., yielding 0.34 parts (26.7%) of potassium 1-[1-(2-chlorophenyl)butyl]-1H-imidazole-5 -carboxylate dihydrate; mp. 70.7° C. (compound 2.14).

Workup

  1. temperatureat reflux temperature
  2. customThe reaction mixture was evaporated
  3. customthe residue was dried in a dry pistol at 70° C.

Sources & evidence

ORD record
ord-92d907ec34444999b53df3234487a387
Source dataset
uspto-grants-1988_09
Patent number
US04770689

Reaction notes

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