Hydrochloric Acid → HCID 86742424, compound

HRID 622342Notes

Reaction equation

HRID 622342 reaction equation
[NH2:1][C@@H:2]1[C:19]2[C@:14]([CH3:21])([CH:15]=[CH:16][C:17](=[O:20])[CH:18]=2)[C@@H:13]2[C@H:4]([C@H:5]3[C@@:9]([CH2:11][CH2:12]2)([CH3:10])[C:8](=[O:22])[CH2:7][CH2:6]3)[CH2:3]1.[ClH:23]>C(O)C>[ClH:23].[NH2:1][C@@H:2]1[C:19]2[C@:14]([CH3:21])([CH:15]=[CH:16][C:17](=[O:20])[CH:18]=2)[C@@H:13]2[C@H:4]([C@H:5]3[C@@:9]([CH2:11][CH2:12]2)([CH3:10])[C:8](=[O:22])[CH2:7][CH2:6]3)[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54573576HCID 54573576, compound

Product 1

HCID 86742424HCID 86742424, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.65 g of 6α-amino androsta-1,4-diene-3,17-dione in 30 ml of ethanol is treated with 21.71 ml of 0.1N HCl aqueous solution. The yellow solution is discoloured, then it is filtered and the alcohol is removed at reduced pressure. The resulting aqueous solution is lyophilized to give 0.7 g of dry 6α-amino androsta-1,4-diene-3,17-dione hydrochloride as slight yellow powder. By analogous procedure the hydrochlorides of the 6-amino derivatives prepared according to the examples 4, 7 and 9 are prepared.

Workup

  1. filtrationit is filtered
  2. customthe alcohol is removed at reduced pressure

Sources & evidence

ORD record
ord-5e85ecaf2bcc43708218dd9f84f0ec93
Source dataset
uspto-grants-1988_09
Patent number
US04771043

Reaction notes

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