反应详情

A mixture prepared from 27 g of 8-acetyl-3-chloro-7,8,9,10-tetrahydro-11H-pyrido[3',4':4,5]pyrrolo[2,3-c]quinoline and 200 ml of concentrated hydrochloric acid was heated at reflux for 1 hour, whereupon a solid precipitated. The mixture was stirred overnight at room temperature, and the solid was filtrated and dissolved in 200 ml of water. This solution was made alkaline with 25% sodium hydroxide solution, and the solid-form free base was filtrated and washed with ethanol. The yield was 17 g, mp=285° C. (dec).

1. temperaturewas heated
2. temperatureat reflux for 1 hour, whereupon a solid
3. customprecipitated
4. filtrationthe solid was filtrated
5. dissolutiondissolved in 200 ml of water
6. filtrationthe solid-form free base was filtrated
7. washwashed with ethanol