反应详情

A mixture of 3.48 g of 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone, 2.03 g of 2-(1-piperazinyl)benzoxazole and 200 ml of absolute ethanol was stirred 18 hours and then filtered. The filtrate was concentrated to dryness and the residue flash chromatographed, eluting with dichloromethane, then 1% methanol in dichloromethane. The desired fraction was evaporated, then recrystallized twice from dichloromethane/ethanol, giving 533 mg of the desired product, mp 190°C. (dec.).

1. filtrationfiltered
2. concentrationThe filtrate was concentrated to dryness
3. customthe residue flash chromatographed
4. washeluting with dichloromethane
5. customThe desired fraction was evaporated
6. customrecrystallized twice from dichloromethane/ethanol