HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Epoxy-2,3-dihydro-1,4-naphthoquinone → HCID 178516903, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Epoxy-2,3-dihydro-1,4-naphthoquinone | HCID 85844 | — |
| Reactant | 2-(Piperazin-1-yl)-1,3-benzoxazole | HCID 647818 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178516903 | HCID 178516903 | 14.2% |
Reaction Steps
A mixture of 3.48 g of 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone, 2.03 g of 2-(1-piperazinyl)benzoxazole and 200 ml of absolute ethanol was stirred 18 hours and then filtered. The filtrate was concentrated to dryness and the residue flash chromatographed, eluting with dichloromethane, then 1% methanol in dichloromethane. The desired fraction was evaporated, then recrystallized twice from dichloromethane/ethanol, giving 533 mg of the desired product, mp 190°C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04771061 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-c9c275ee3d4048caafed3b4a8ac326c2 |
| Source note | uspto-grants-1988_09 |