反应详情

0.63 ml of chloroacetonitrile was added to a solution of 23 mg of metallic sodium in 4 ml of absolute methanol, and the mixture was stirred for about 30 minutes at room temperature. 1.5 g of 4-hydroxyiminopiperidine hydrochloride were then added and the stirring was continued for 2 hours, during which time a precipitate separated out. 25 ml of anhydrous ether were added to the reaction mixture, and the precipitated crystals were collected by filtration and washed with ether, giving 2.22 g of 2-(4-hydroxyiminopiperidin-1-yl)-2-iminoethylchloride hydrochloride.

1. waitthe stirring was continued for 2 hours, during which time
2. customa precipitate separated out
3. addition25 ml of anhydrous ether were added to the reaction mixture
4. filtrationthe precipitated crystals were collected by filtration
5. washwashed with ether