反应详情

2 ml of a methanolic solution containing 1.064 g of 4-methoxyiminopiperidine was added to a solution of 1.195 g of methyl 2-chloroacetimidate hydrochloride in 4 ml of absolute methanol, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off and the concentrate was mixed with anhydrous ether. The crystals which separated out were collected by filtration and washed with ether, giving 1.5 g of 2-(4-methoxyiminopiperidin-1-yl)-2-iminoethylchloride hydrochloride.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. additionthe concentrate was mixed with anhydrous ether
4. customThe crystals which separated out
5. filtrationwere collected by filtration
6. washwashed with ether