Ammonia → N-(piperidin-4-ylidene)hydroxylamine hydrochloride

HRID 622445Notes

Reaction equation

HRID 622445 reaction equation
[NH3:1].[OH2:2].[ClH:3].[NH:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1.Cl.NO>>[ClH:3].[OH:2][N:1]=[C:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 443297Hydroxyamine hydrochlorideHCID 2723901Piperonylamine

Product 1

HCID 19106851N-(piperidin-4-ylidene)hydroxylamine hydrochloride

Procedure

5.4 ml of 28% aqueous ammonia solution were added to a mixture of 3.0 g of 4-piperidone hydrochloride monohydrate and 1.63 g of hydroxylamine hydrochloride, and the resulting mixture was stirred for 2 hours at 80° to 90° C. After completion of the reaction, the solvent was distilled off and the crystalline residue was recrystallized from methanol, giving 1.8 g of the title compound.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. customthe crystalline residue was recrystallized from methanol

Sources & evidence

ORD record
ord-80b94ece8c8f4474b6d21046d9efcd01
Source dataset
uspto-grants-1988_09
Patent number
US04771046

Reaction notes

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