HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 622454Generated: November 4, 2026
Hydrochloric Acid → 1-Methylpiperazin-2-one--hydrogen chloride (1/1)
https://huagongshe.com/reaction/622454
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Tert-butyl 4-methyl-3-oxopiperazine-1-carboxylate | HCID 18783916 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Methylpiperazin-2-one--hydrogen chloride (1/1) | HCID 17060766 | — |
Reaction Steps
14 ml of 3M hydrogen chloride in ethyl acetate were added to 3.0 g of the product obtained in step (1) above, and the mixture was stirred at 35° C. for one hour. Diethyl ether was added to the reaction mixture, and the crystals which precipitated out were collected by filtration, washed with diethyl ether and dried, to give 2.1 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04771046 |
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| Source dataset | uspto-grants-1988_09 |
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| ORD ID | ord-15b6f314ae074a29829bf95cac8ef287 |
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| Source note | uspto-grants-1988_09 |
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