Hydrochloric Acid → 1-Methylpiperazin-2-one--hydrogen chloride (1/1)

HRID 622454Notes

Reaction equation

HRID 622454 reaction equation
[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][C:4]1=[O:16].C(OCC)C>C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][NH:6][CH2:5][C:4]1=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 18783916Tert-butyl 4-methyl-3-oxopiperazine-1-carboxylate

Product 1

HCID 170607661-Methylpiperazin-2-one--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
35 °C

Procedure

14 ml of 3M hydrogen chloride in ethyl acetate were added to 3.0 g of the product obtained in step (1) above, and the mixture was stirred at 35° C. for one hour. Diethyl ether was added to the reaction mixture, and the crystals which precipitated out were collected by filtration, washed with diethyl ether and dried, to give 2.1 g of the title compound.

Workup

  1. customthe crystals which precipitated out
  2. filtrationwere collected by filtration
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-15b6f314ae074a29829bf95cac8ef287
Source dataset
uspto-grants-1988_09
Patent number
US04771046

Reaction notes

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