反应详情

A solution of 0.32 g (0.76 mmol) ethyl 7-[2-(acetamidomethyl)-4-thiazolyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate in 3 ml 6N hydrochloric acid was stirred at reflux three hours. The mixture was evaporated to dryness and the resulting solid was suspended in 5 ml water and dissolved by addition of 1N sodium hydroxide to pH 11. After filtration the product was precipitated by addition of 1N hydrochloric acid to pH 6.2, filtered, washed with water and dried to afford 0.22 g 7-[2-aminomethyl)-4-thiazolyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 249°-254° C. (dec).

1. temperatureat reflux three hours
2. customThe mixture was evaporated to dryness
3. dissolutiondissolved by addition of 1N sodium hydroxide to pH 11
4. filtrationAfter filtration the product
5. customwas precipitated by addition of 1N hydrochloric acid to pH 6.2
6. filtrationfiltered
7. washwashed with water
8. customdried