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HRID622516

反应详情

EQUATION

反应方程式

HRID 622516 的结构方程式

REACTANTS

反应物

3
结构：C1CCC2=NCCCN2CC1
HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O
HCID11055142

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

C12H8ClFN2O3

结构：CC(C)NCC1CCNC1
HCID13491802

N-[(Pyrrolidin-3-yl)methyl]propan-2-amine

C8H18N2

PRODUCTS

生成物

1
结构：CC(C)NCC1CCN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C1
HCID13772748

未命名化合物

收率 111.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A suspension of 1.13 g (3.0 mmole) of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, 0.63 g (4.4 mmole) of 3-[(2-propyl)aminomethyl]pyrrolidine, 1.22 g (8.0 mmole) of 1,8-diazabicyclo[5.4.0]undec-7-ene and 30 ml of acetonitrile was stirred at room temperature for two hours. The precipitate was removed by filtration, washed with acetonitrile, and dried in vacuo to give 1.3 g (84%) of the title compound, mp 240°-243° C.

WORKUP

后处理

  1. customThe precipitate was removed by filtration
  2. washwashed with acetonitrile
  3. customdried in vacuo