Hydrochloric Acid → HCID 13755216, compound

Participants

Reaction Steps

5 g (0.015 mole) of 5-propionamido-1-(3,5-dichloropyrid-2-yl)-4-nitro-pyrazole and 10 ml of concentrated hydrochloric acid are heated under reflux in 15 ml of ethanol for 4 hours, the solvent is distilled off in vacuo, the residue is taken up in 400 ml of methylene chloride and the mixture is neutralized with sodium bicarbonate solution, washed with sodium chloride solution, dried over sodium sulphate and freed from the solvent in vacuo. 3.8 g (92% of theory) of 5-amino-1-(3,5-dichloropyrid-2-yl)-4-nitropyrazole of melting point 194° C. are obtained.

Provenance & Evidence