Hydrochloric Acid → HCID 13755216, compound

HRID 622613Notes

Reaction equation

HRID 622613 reaction equation
C([NH:5][C:6]1[N:10]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([Cl:18])=[CH:13][N:12]=2)[N:9]=[CH:8][C:7]=1[N+:19]([O-:21])=[O:20])(=O)CC.Cl>C(O)C>[NH2:5][C:6]1[N:10]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([Cl:18])=[CH:13][N:12]=2)[N:9]=[CH:8][C:7]=1[N+:19]([O-:21])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13755215HCID 13755215, compound

Product 1

HCID 13755216HCID 13755216, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g (0.015 mole) of 5-propionamido-1-(3,5-dichloropyrid-2-yl)-4-nitro-pyrazole and 10 ml of concentrated hydrochloric acid are heated under reflux in 15 ml of ethanol for 4 hours, the solvent is distilled off in vacuo, the residue is taken up in 400 ml of methylene chloride and the mixture is neutralized with sodium bicarbonate solution, washed with sodium chloride solution, dried over sodium sulphate and freed from the solvent in vacuo. 3.8 g (92% of theory) of 5-amino-1-(3,5-dichloropyrid-2-yl)-4-nitropyrazole of melting point 194° C. are obtained.

Workup

  1. distillationthe solvent is distilled off in vacuo
  2. washwashed with sodium chloride solution
  3. dry with materialdried over sodium sulphate

Sources & evidence

ORD record
ord-e3da4e43c05746b7b37ab236bd28ed8f
Source dataset
uspto-grants-1988_09
Patent number
US04772312

Reaction notes

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