HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oleoyl chloride → palmitoyl-Leu-Pro-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oleoyl chloride | HCID 5364783 | — |
| Reactant | Methyl N6-((benzyloxy)carbonyl)-L-lysyl-L-prolinate, 2,2,2-trifluoroacetate salt | HCID 131667640 | — |
| Solvent | N-Carbobenzoxy-L-valine | HCID 726987 | — |
| Solvent | H-Leu-Leu-Pro-OMe | HCID 131715721 | — |
| Product | palmitoyl-Leu-Pro-OMe | HCID 131715720 | — |
Reaction Steps
Instead of oleoyl chloride in (b), (a) palmitoyl chloride, (b) stearoyl chloride and (c) linoleolyl chloride were used to obtain (a') palmitoyl-Leu-Pro-OMe (SUAM 1141), (b') stearoyl-Leu-Pro-OMe (SUAM 1142) and (c') linoleoyl-Leu-Pro-OMe (SUAM 1143), respectively. Further, instead of H-Leu-Pro-OMe in (b), (d) H-Val-Pro-OMe, (e) H-Ala-Pro-OMe (f) H-Leu-Leu-Pro-OMe, (g) H-Phe-Pro-OMe, (h) H-Met-Pro-OMe and (i) H-norLeu-Pro-OMe were used to obtain (d') oleoyl-Val-Pro-OMe (SUAM 1147), (e') oleoyl -Ala-Pro-OMe (SUAM 1076), (f') oleoyl-Leu-Leu-Pro-OMe (SUAM 1159), (g') oleoyl-Phe-Pro-OMe (SUAM) 1194), (h') oleoyl-Met-Pro-OMe (SUAM 1198) and (i') oleoyl-norLeu-Pro-OMe (SUAM 1164), as oils, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04772587 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-769ae782d43b448698f48b4977beb9eb |
| Source note | uspto-grants-1988_09 |