Ammonia → HCID 20040999, compound

HRID 622648Notes

Reaction equation

HRID 622648 reaction equation
C[O:2][C:3]([CH:5]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[C:8](=[O:21])[CH2:7][CH2:6]1)=O.[NH3:22]>CO>[OH2:2].[OH2:2].[CH3:20][N:17]1[CH2:18][CH2:19][N:14]([CH2:13][C:12]#[C:11][CH2:10][N:9]2[C:8](=[O:21])[CH2:7][CH2:6][CH:5]2[C:3]([NH2:22])=[O:2])[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14254900HCID 14254900, compound

Product 1

HCID 20040999HCID 20040999, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An ice water chilled solution of 5-methoxycarbonyl-1-[4-(4-methyl-1-piperazinyl)-2-butynyl]-2-pyrrolidinone (5.02 g) in sieve dried methanol (150 ml) was treated with anhydrous ammonia for fifteen minutes and was allowed to stand at ambient temperture overnight. The solution was concentrated to an amber oil.

Workup

  1. concentrationThe solution was concentrated to an amber oil

Sources & evidence

ORD record
ord-cafa44552cc84623b1dd1689acf2aca5
Source dataset
uspto-grants-1988_09
Patent number
US04772601

Reaction notes

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