Echinopsine → HCID 21291473, compound

HRID 622682Notes

Reaction equation

HRID 622682 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[CH:4]=[CH:3]1.[Cl:13][S:14](O)(=[O:16])=[O:15]>>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[C:4]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:3]1

Participants

3

Reactant 2

HCID 6748EchinopsineHCID 24638Chlorosulfonic acid

Product 1

HCID 21291473HCID 21291473, compound

Procedure

1-Methyl-4-quinolone (2 g) was heated with chlorosulphonic acid (5 ml) at 125° for 2.5 hours. The reaction mixture was cooled to room temperature and then carefully poured onto crushed ice (300 ml). The precipitated solid was collected by filtration and then dried to give the novel compound 1-methyl-4-oxo-1,4-dihydroquinoline-3-sulphonyl chloride, m.p. 313°-315°.

Workup

  1. additioncarefully poured
  2. filtrationThe precipitated solid was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-50fd0e9d58684ef096160e9a9271677a
Source dataset
uspto-grants-1988_09
Patent number
US04772614

Reaction notes

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