Dimethylamine → HCID 21291465, compound

HRID 622690Notes

Reaction equation

HRID 622690 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[C:5](=[O:16])[C:4]([S:17](Cl)(=[O:19])=[O:18])=[CH:3]1.[CH3:21][NH:22][CH3:23]>>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[C:5](=[O:16])[C:4]([S:17]([N:22]([CH3:23])[CH3:21])(=[O:19])=[O:18])=[CH:3]1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 21291493HCID 21291493, compound

Product 1

HCID 21291465HCID 21291465, compound

Procedure

1-Methyl-4-oxo-7-trifluoromethyl-1,4-dihydroquinoline-3-sulphonyl chloride (12.4 g) was added to a stirred solution of dimethylamine in industrial methylated spirit (33% w/w; 230 ml) and the mixture was kept at ambient temperature for 27 hours. The mixture was evaporated to dryness and the residue was recrystallised from industrial methylated spirit using charcoal to give the novel compound 1,N,N-trimethyl-4-oxo-7-trifluoromethyl-1,4-dihydroquinoline-3-sulphonamide, m.p. 221°-223°.

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe residue was recrystallised from industrial methylated spirit

Sources & evidence

ORD record
ord-e2cc4f48e1da4a75a56895d02d3d0dfe
Source dataset
uspto-grants-1988_09
Patent number
US04772614

Reaction notes

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