N,N-Dimethylmethanesulphonamide → HCID 21291506, compound

HRID 622694Notes

Reaction equation

HRID 622694 reaction equation
[CH3:1][N:2]([CH3:7])[S:3]([CH3:6])(=[O:5])=[O:4].C([Li])CCC.[NH2:13][C:14]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:15]=1[C:16](OCC)=[O:17]>>[NH2:13][C:14]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:15]=1[C:16](=[O:17])[CH2:6][S:3](=[O:5])(=[O:4])[N:2]([CH3:7])[CH3:1]

Participants

4

Reactant 3

HCID 70191N,N-DimethylmethanesulphonamideHCID 21291483Ethyl 2-amino-5-methoxybenzoateHCID 178418339Butyllithium

Product 1

HCID 21291506HCID 21291506, compound

Procedure

In a similar manner to that described in Example 12(a), N,N-dimethylmethanesulphonamide was reacted with n-butyl lithium and the product was reacted with ethyl 2-amino-5-methoxybenzoate to give the novel compound 1-(2-amino-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone, m.p. 198°-200°.

Sources & evidence

ORD record
ord-87820ce0e9544d7c91daa3f8a707e23e
Source dataset
uspto-grants-1988_09
Patent number
US04772614

Reaction notes

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