Hydrochloric Acid → HCID 9819590, compound

HRID 622743Notes

Reaction equation

HRID 622743 reaction equation
[Cl:1][C:2]1[C:17]([C:18]#[N:19])=[CH:16][C:5]([C:6]([NH:8][CH2:9][CH2:10][N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[O:7])=[C:4]([O:20][CH3:21])[CH:3]=1.Cl>CC(C)=O>[ClH:1].[Cl:1][C:2]1[C:17]([C:18]#[N:19])=[CH:16][C:5]([C:6]([NH:8][CH2:9][CH2:10][N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[O:7])=[C:4]([O:20][CH3:21])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 9819591HCID 9819591, compound

Product 1

HCID 9819590HCID 9819590, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

30 g of 4-chloro-5-cyano-N-(2-diethylaminoethyl)-2-methoxybenzamide are dissolved in 100 ml of acetone and, while stirring and cooling with ice, the pH is adjusted to 5 with ethereal hydrochloric acid, the hydrochloride crystallising out. The crystals are filtered off with suction and washed twice with a small amount of acetone, the salt is dried under a high vacuum at 60° and 4-chloro-5-cyano-N-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride having a melting point of 189°-190° (decomposition) is obtained.

Workup

  1. temperaturecooling with ice
  2. filtrationThe crystals are filtered off with suction
  3. washwashed twice with a small amount of acetone
  4. customthe salt is dried under a high vacuum at 60°

Sources & evidence

ORD record
ord-79a8c4ef15724a2fa4baac94fc28ca72
Source dataset
uspto-grants-1988_09
Patent number
US04772630

Reaction notes

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