1,3-dichloro-2-phenylpropan-2-ol → HCID 13986037, compound

HRID 623202Notes

Reaction equation

HRID 623202 reaction equation
Cl[CH2:2][C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([OH:6])[CH2:4]Cl.[C:13]1(=[O:23])[NH:17][C:16](=[O:18])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12.[K]>CN(C)C=O>[C:13]1(=[O:23])[N:17]([CH2:2][C:3]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)([OH:6])[CH2:4][N:17]2[C:16](=[O:18])[C:15]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]3[C:13]2=[O:23])[C:16](=[O:18])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12

Participants

4

Reactant 2

HCID 2325951,3-dichloro-2-phenylpropan-2-olHCID 24194345Phthalimide potassium salt

Product 1

HCID 13986037HCID 13986037, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 30.6 g (0.149 mol) of 1,3-dichloro-2-phenylpropan-2-ol, 55.5 g (0.300 mol) of potassium phthalimide and 300 ml of dimethylformamide is heated in a water bath at 100° C. for 4 h. The resulting reaction medium is cooled and evaporated until the volume has been halved, and the insoluble material formed is filtered off, washed with CH3OH and then dried to give 40 g (yield: 63%) of 1,3-diphthalimido-2-phenylpropan-2-ol.

Workup

  1. customThe resulting reaction medium
  2. temperatureis cooled
  3. customevaporated until the volume
  4. customthe insoluble material formed
  5. filtrationis filtered off
  6. washwashed with CH3OH
  7. customdried

Sources & evidence

ORD record
ord-33ad644537c44ab9bdd020d6cacd0f28
Source dataset
uspto-grants-1988_09
Patent number
US04774248

Reaction notes

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