HCID 21290604, compound → HCID 14010516, compound

HRID 623206Notes

Reaction equation

HRID 623206 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH2:13][NH2:14])[CH2:11][NH2:12])=[CH:6][CH:5]=1>O.[OH-].[Na+]>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH2:13][NH2:14])[CH2:11][NH2:12])=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 21290604HCID 21290604, compound

Product 1

HCID 14010516HCID 14010516, compoundYield 96.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

30 g (0.1165 mol) of 2-(4-chlorophenyl)propane-1,3-diamine dihydrochloride are dissolved in the minimum quantity of water, NaOH is added until the pH is 11, the mixture is extracted with 4×100 ml of chloroform, the chloroform phase is washed with 50 ml of water, dried over MgSO4 and filtered, and the filtrate is evaporated to dryness to give 20.8 g (0.1127 mol) of 2-(4-chlorophenyl)propane-1,3-diamine.

Workup

  1. additionis added until the pH is 11
  2. extractionthe mixture is extracted with 4×100 ml of chloroform
  3. washthe chloroform phase is washed with 50 ml of water
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-83325eb25da440a4b4399fe21e4b4824
Source dataset
uspto-grants-1988_09
Patent number
US04774248

Reaction notes

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