Romazarit → Sodium 2-{[2-(4-chlorophenyl)-4-methyl-1,3-oxazol-5-yl]methoxy}-2-methylpropanoate

Participants

Reaction Steps

10.0 ml of 1M sodium isopropoxide solution in isopropanol were added to a warm stirred solution of 3.09 g (10 mmol) of 2-[[2-(4-chlorophenyl)-4-methyl-5-oxazolyl]methoxy]-2-methylpropionic acid in 30 ml of isopropanol and the mixture was allowed to cool slowly to give 3.0 g (90%) of sodium 2-[[2-(4-chlorophenyl)-4-methyl-5-oxazolyl]methoxy]-2-methylpropionate in the form of a colourless crystalline solid of melting point 277°-278° C.

Provenance & Evidence