Romazarit → Sodium 2-{[2-(4-chlorophenyl)-4-methyl-1,3-oxazol-5-yl]methoxy}-2-methylpropanoate

HRID 623228Notes

Reaction equation

HRID 623228 reaction equation
CC(C)[O-].[Na+:5].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[O:14][C:15]([CH2:19][O:20][C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23])=[C:16]([CH3:18])[N:17]=2)=[CH:9][CH:8]=1>C(O)(C)C>[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[O:14][C:15]([CH2:19][O:20][C:21]([CH3:26])([CH3:25])[C:22]([O-:24])=[O:23])=[C:16]([CH3:18])[N:17]=2)=[CH:9][CH:8]=1.[Na+:5]

Participants

4

Reactant 2

HCID 71321RomazaritHCID 109204432-Propanol, sodium salt (1:1)

Product 1

HCID 23663984Sodium 2-{[2-(4-chlorophenyl)-4-methyl-1,3-oxazol-5-yl]methoxy}-2-methylpropanoateYield 90%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

10.0 ml of 1M sodium isopropoxide solution in isopropanol were added to a warm stirred solution of 3.09 g (10 mmol) of 2-[[2-(4-chlorophenyl)-4-methyl-5-oxazolyl]methoxy]-2-methylpropionic acid in 30 ml of isopropanol and the mixture was allowed to cool slowly to give 3.0 g (90%) of sodium 2-[[2-(4-chlorophenyl)-4-methyl-5-oxazolyl]methoxy]-2-methylpropionate in the form of a colourless crystalline solid of melting point 277°-278° C.

Workup

  1. temperatureto cool slowly

Sources & evidence

ORD record
ord-af8a08ab1015437db6a3927600933504
Source dataset
uspto-grants-1988_09
Patent number
US04774253

Reaction notes

Loading…