反应详情

53 mg (0.33 mmol) of 2-chloro-5-chloromethyl pyridine dissolved in 6 ml of anhydrous acetonitrile was added to 68 mg (0.33 mmol) of the 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the aforementioned method, and subsequently, 50 mg (0.36 mmol) of potassium carbonate was added thereto and the resulting mixture was heated and refluxed for 1 hours. After the reaction was completed, the reaction solution was returned to room temperature and then concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected and dried to obtain the subject material. Amount obtained 49 mg (yield 45%).

1. customsynthesized by the aforementioned method
2. temperaturethe resulting mixture was heated
3. temperaturerefluxed for 1 hours
4. customwas returned to room temperature
5. concentrationconcentrated under reduced pressure
6. additionDiethyl ether was added
7. customto precipitate a solid
8. customthus the solid was collected
9. customdried
10. customto obtain the subject material
11. customAmount obtained 49 mg (yield 45%)