1-(6-Chloropyridin-3-yl)ethan-1-one → HCID 67509657, compound

HRID 623460Notes

Reaction equation

HRID 623460 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[F:11][C:12]([F:16])([F:15])[CH2:13][SH:14]>>[F:11][C:12]([F:16])([F:15])[CH2:13][S:14][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27796981-(6-Chloropyridin-3-yl)ethan-1-oneHCID 41339242,2,2-Trifluoroethanethiol

Product 1

HCID 67509657HCID 67509657, compoundYield 64%

Procedure

The title compound is prepared in 64% yield (0.39 g, an orange solid) from 1-(6-chloropyridin-3-yl)ethanone (0.40 g, 2.54 mmol) and 2,2,2-trifluoroethanethiol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.

Sources & evidence

ORD record
ord-97cf426ceb5e4a5b80bfd25a4ae1908b
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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