反应详情

温度

50 °C

Hydrazine hydrate (0.13 mL) is added to a solution of 2-((2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isoindoline-1,3-dione (0.67 g, 1.83 mmol) in methanol (20 mL) and stirred for 20 hours at 50° C. After removal of the solvent, the residue is poured into 2N sodium hydroxide (10 mL) and extracted with dichloromethane (30 mL×3) and dried over sodium sulfate, and concentrated in vacuo to give 0.41 g (95% yield) of the title compound as a white solid.

1. customAfter removal of the solvent
2. additionthe residue is poured into 2N sodium hydroxide (10 mL)
3. extractionextracted with dichloromethane (30 mL×3)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo