Iodoethane → HCID 67509455, compound

HRID 623466Notes

Reaction equation

[F:1][C:2]([F:22])([F:21])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:12])=[CH:7][CH:6]=1.I[CH2:24][CH3:25]>>[CH2:24]([N:13]([CH:11]([C:8]1[CH:9]=[N:10][C:5]([O:4][CH2:3][C:2]([F:1])([F:21])[F:22])=[CH:6][CH:7]=1)[CH3:12])[C:14](=[O:20])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH3:25]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 131735178HCID 131735178, compound

Product 1

HCID 67509455HCID 67509455, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (0.24 g, colorless oil) from tert-butyl (1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamate (0.22 g, 0.69 mmol, Step-1 of Amine-3) and iodoethane instead of iodomethane by the similar manner in Step-2 of Amine-3.

Sources & evidence

ORD record: ord-757ed37cccbd413296d57b6698435736
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

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