2-(2,2,2-Trifluoroethoxy)ethan-1-ol → HCID 67509694, compound

HRID 623471Notes

Reaction equation

HRID 623471 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[F:11][C:12]([F:19])([F:18])[CH2:13][O:14][CH2:15][CH2:16][OH:17]>>[F:11][C:12]([F:19])([F:18])[CH2:13][O:14][CH2:15][CH2:16][O:17][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-olHCID 27796981-(6-Chloropyridin-3-yl)ethan-1-one

Product 1

HCID 67509694HCID 67509694, compoundYield 50%

Procedure

The title compound is prepared in 50% yield (1.67 g, colorless oil) from 1-(6-chloropyridin-3-yl)ethanone (2.0 g, 12.9 mmol) and 2-(2,2,2-trifluoroethoxy)ethanol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-2.

Sources & evidence

ORD record
ord-b7fd9e79329f4591a1c0d0fc34e96ed3
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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