2,2-Difluoroethan-1-ol → HCID 82006899, compound

HRID 623473Notes

Reaction equation

HRID 623473 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[F:11][CH:12]([F:15])[CH2:13][OH:14]>>[F:11][CH:12]([F:15])[CH2:13][O:14][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1361872,2-Difluoroethan-1-olHCID 27796981-(6-Chloropyridin-3-yl)ethan-1-one

Product 1

HCID 82006899HCID 82006899, compoundYield 71%

Procedure

The title compound is prepared in 71% yield (1.34 g, a white solid) from 1-(6-chloropyridin-3-yl)ethanone (1.5 g, 9.64 mmol) and 2,2-difluoroethanol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-2.

Sources & evidence

ORD record
ord-8c97458e02e24a0ea9fecbc932835807
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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