2,2-Difluoroethan-1-ol → HCID 87426353, compound

HRID 623515Notes

Reaction equation

HRID 623515 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:12][CH:13]([F:16])[CH2:14][OH:15]>>[Br:1][C:2]1[C:3]([O:15][CH2:14][CH:13]([F:16])[F:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 1361872,2-Difluoroethan-1-olHCID 2854335-Bromo-6-chloropyridine-3-carboxylic acid

Product 1

HCID 87426353HCID 87426353, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (4.7 g, a pale orange solid) from 5-bromo-6-chloronicotinic acid (3.0 g, 12.7 mmol) and 2,2-difluoroethanol (2.1 g, 25.4 mmol) instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.

Sources & evidence

ORD record
ord-5890abd54fe54f3ca3481e342c0048f4
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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