HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoroethan-1-ol → HCID 87426353, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Product | HCID 87426353 | HCID 87426353 | 99% |
Reaction Steps
The title compound is prepared in >99% yield (4.7 g, a pale orange solid) from 5-bromo-6-chloronicotinic acid (3.0 g, 12.7 mmol) and 2,2-difluoroethanol (2.1 g, 25.4 mmol) instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-5890abd54fe54f3ca3481e342c0048f4 |
| Source note | uspto-grants-2016_04 |