HCID 87426398, compound → HCID 87426381, compound

HRID 623516Notes

Reaction equation

HRID 623516 reaction equation
Br[C:2]1[C:3]([O:12][CH2:13][CH:14]([F:16])[F:15])=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[CH2:17]([Zn]CC)[CH3:18]>>[F:15][CH:14]([F:16])[CH2:13][O:12][C:3]1[C:2]([CH2:17][CH3:18])=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 87426398HCID 87426398, compoundHCID 178418750HCID 178418750, compound

Product 1

HCID 87426381HCID 87426381, compoundYield 88%

Procedure

The title compound is prepared in 88% yield (660 mg, clear colorless oil) from methyl 5-bromo-6-(2,2-difluoroethoxy)nicotinate (900 mg, 3.0 mmol, Step-2) and diethylzinc instead of dimethylzinc by the similar manner in Step-3 of Amine-27.

Sources & evidence

ORD record
ord-918cbf8d03b34840a6fc01a0ec899fd1
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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