tert-Butylsulfinamide, (R)-(+)- → HCID 67510091, compound

HRID 623528Notes

Reaction equation

HRID 623528 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:13](=O)[CH3:14])[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:14])[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 177507411-[3-Chloro-5-(trifluoromethoxy)phenyl]ethan-1-one

Product 1

HCID 67510091HCID 67510091, compoundYield 48%

Procedure

The title compound is prepared in 48% yield (416 mg, a white solid) from 1-(3-chloro-5-(trifluoromethoxy)phenyl)ethanone (600 mg, 2.51 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide (457 mg, 3.77 mmol) by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-d6256ec4319247ee8cc224e4104e33d7
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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