1-[2-Fluoro-3-(trifluoromethyl)phenyl]ethan-1-one → HCID 67510352, compound

HRID 623529Notes

Reaction equation

HRID 623529 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12](=O)[CH3:13].[CH3:15][C:16]([S@:19]([NH2:21])=[O:20])([CH3:18])[CH3:17]>>[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]([NH:21][S@@:19]([C:16]([CH3:18])([CH3:17])[CH3:15])=[O:20])[CH3:13]

Participants

3

Reactant 2

HCID 27375291-[2-Fluoro-3-(trifluoromethyl)phenyl]ethan-1-oneHCID 10964479tert-Butylsulfinamide, (R)-(+)-

Product 1

HCID 67510352HCID 67510352, compoundYield 56%

Procedure

The title compound is prepared in 56% yield (511 mg, a white solid) from 1-(2-fluoro-3-(trifluoromethyl)phenyl)ethanone (600 mg, 2.91 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide (529 mg, 4.37 mmol) by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-61e41916fe824be4a39133526deef34f
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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