2,2-Difluoroethan-1-ol → HCID 87426976, compound

HRID 623530Notes

Reaction equation

HRID 623530 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[O:11][CH3:12].[F:13][CH:14]([F:17])[CH2:15][OH:16]>>[F:13][CH:14]([F:17])[CH2:15][O:16][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 1361872,2-Difluoroethan-1-olHCID 87426205HCID 87426205, compound

Product 1

HCID 87426976HCID 87426976, compoundYield 72%

Procedure

The title compound is prepared in 72% yield (0.94 g, a white solid) from 1-(6-chloro-5-methoxypyridin-3-yl)ethanone (1.04 g, 5.60 mmol, Step-2 of Amine-22) and 2,2-difluoroethanol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-2.

Sources & evidence

ORD record
ord-191931730e69467ebe55dd029b4245aa
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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