2,2-Difluoroethyl trifluoromethanesulfonate → HCID 87426370, compound

HRID 623534Notes

Reaction equation

HRID 623534 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].FC(F)(F)S(O[CH2:18][CH:19]([F:21])[F:20])(=O)=O>>[Cl:1][C:2]1[N:10]=[C:9]([O:11][CH2:18][CH:19]([F:20])[F:21])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:18][CH:19]([F:21])[F:20])=[O:5]

Participants

3

Reactant 2

HCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 178524498HCID 178524498, compound

Product 1

HCID 87426370HCID 87426370, compoundYield 92%

Procedure

The title compound is prepared in 92% yield (2.9 g, clear colorless oil) from 2-chloro-6-hydroxynicotinic acid (1.8 g, 11 mmol) and 2,2-difluoroethyl trifluoromethanesulfonate instead of 2,2,2-trifluoroethyl trifluoromethanesulfonate by the similar manner in Step-3 of Amine-13.

Sources & evidence

ORD record
ord-fa5dbdae3f9b48ea877a81f261416d06
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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