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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623534Generated: October 31, 2026

2,2-Difluoroethyl trifluoromethanesulfonate → HCID 87426370, compound

https://huagongshe.com/reaction/623534

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2-Difluoroethyl trifluoromethanesulfonateHCID 2774089—
ReactantHCID 178524498HCID 178524498—
ProductHCID 87426370HCID 8742637092%

Reaction Steps

The title compound is prepared in 92% yield (2.9 g, clear colorless oil) from 2-chloro-6-hydroxynicotinic acid (1.8 g, 11 mmol) and 2,2-difluoroethyl trifluoromethanesulfonate instead of 2,2,2-trifluoroethyl trifluoromethanesulfonate by the similar manner in Step-3 of Amine-13.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-fa5dbdae3f9b48ea877a81f261416d06
Source noteuspto-grants-2016_04