tert-Butylsulfinamide, (R)-(+)- → (R)-N-(1-(3-(difluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

HRID 623548Notes

Reaction equation

HRID 623548 reaction equation
[F:1][CH:2]([F:12])[C:3]1[CH:4]=[C:5]([C:9](=O)[CH3:10])[CH:6]=[CH:7][CH:8]=1.[CH3:13][C:14]([S@:17]([NH2:19])=[O:18])([CH3:16])[CH3:15]>>[F:1][CH:2]([F:12])[C:3]1[CH:4]=[C:5]([CH:9]([NH:19][S@@:17]([C:14]([CH3:16])([CH3:15])[CH3:13])=[O:18])[CH3:10])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 675101191-(3-(Difluoromethyl)phenyl)ethan-1-one

Product 1

HCID 67511126(R)-N-(1-(3-(difluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamideYield 56%

Procedure

The title compound is prepared in 56% yield (0.53 g, colorless oil) from 1-(3-(difluoromethyl)phenyl)ethanone (0.58 g, 3.41 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-85d3a49071b74f97a2170c24a30562a3
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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