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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623548Generated: October 27, 2026

tert-Butylsulfinamide, (R)-(+)- → (R)-N-(1-(3-(difluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

https://huagongshe.com/reaction/623548

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butylsulfinamide, (R)-(+)-HCID 10964479—
Reactant1-(3-(Difluoromethyl)phenyl)ethan-1-oneHCID 67510119—
Product(R)-N-(1-(3-(difluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamideHCID 6751112656%

Reaction Steps

The title compound is prepared in 56% yield (0.53 g, colorless oil) from 1-(3-(difluoromethyl)phenyl)ethanone (0.58 g, 3.41 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-85d3a49071b74f97a2170c24a30562a3
Source noteuspto-grants-2016_04