Cyclopropanecarbonyl chloride → HCID 67508714, compound

HRID 623552Notes

Reaction equation

HRID 623552 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:12]1([C:15](Cl)=[O:16])[CH2:14][CH2:13]1>>[CH:12]1([C:15]([NH:1][C:2]2[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=2)[C:5]([O:7][CH3:8])=[O:6])=[O:16])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 236984Methyl 2-aminopyridine-4-carboxylate

Product 1

HCID 67508714HCID 67508714, compoundYield 92%

Procedure

The title compound is prepared in 92% yield (1.60 g, a yellow solid) from methyl 2-aminoisonicotinate (1.20 g, 7.89 mmol) and cyclopropanecarbonyl chloride by the similar manner in Step-1 of Carboxylic acid-1.

Sources & evidence

ORD record
ord-a0cd301bc448472480b7110c7221da7b
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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