Pivaloyl chloride → Methyl 2-(2,2-dimethylpropanamido)pyridine-4-carboxylate

HRID 623560Notes

Reaction equation

Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][N:12]=1)[C:6]([O:8][CH3:9])=[O:7].[C:13](Cl)(=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15]>>[C:13]([NH:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][N:12]=1)[C:6]([O:8][CH3:9])=[O:7])(=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15]

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 67509862methyl 2-aminoisonicotinate hydrochloride（WS204501）

Product 1

HCID 17750159Methyl 2-(2,2-dimethylpropanamido)pyridine-4-carboxylate

Procedure

The title compound is prepared in quantitative yield (1.25 g, colorless syrup) from methyl 2-aminoisonicotinate hydrochloride (1.00 g, 5.30 mmol) and pivaloyl chloride by the similar manner in Step-1 of Carboxylic acid-1.

Sources & evidence

ORD record: ord-5f758960652640a5ae7f03a2bb1e955b
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

Loading…