Methyl 2-Chloro-6-methylisonicotinate → Methyl 2-(2-acetoxy-2-methylpropanamido)-6-methylisonicotinate

HRID 623566Notes

Reaction equation

HRID 623566 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:13]([O:16][C:17]([CH3:22])([CH3:21])[C:18]([NH2:20])=[O:19])(=[O:15])[CH3:14]>>[C:13]([O:16][C:17]([CH3:22])([CH3:21])[C:18]([NH:20][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6])=[O:19])(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 2759833Methyl 2-Chloro-6-methylisonicotinateHCID 124355421-Amino-2-methyl-1-oxopropan-2-yl acetate

Product 1

HCID 67510446Methyl 2-(2-acetoxy-2-methylpropanamido)-6-methylisonicotinateYield 80%

Procedure

The title compound is prepared in 80% yield (0.89 g, a yellow solid) from methyl 2-chloro-6-methylisonicotinate (0.70 g, 3.8 mmol) and 1-amino-2-methyl-1-oxopropan-2-yl acetate by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-c2262ef6324c4efca35108b0b21ad87f
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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